One of the first records DJ Jazzy Jeff ever appeared on was with the Korner Boyz (Street Artz Records) and their songs "Bust the Move" and "The Saga of Roxanne", which featured legendary Philadelphia rappers MC Parry P and Grand Tone. The instrumental was called "Jazzy Jeff Scratch" (1985).
As a duo, DJ Jazzy Jeff & the Fresh Prince had several gold and platinum-selling albums and singles in the late 1980s and early 1990s, earning them the first rap Grammy Award ever presented in 1989 for "Parents Just Don't Understand"
DJ Jazzy Jeff & the Fresh Prince also won a second Grammy for "Summertime".
After DJ Jazzy Jeff & the Fresh Prince broke up, Townes went on to become a prominent R&B, soul, and neo soul record producer, establishing the A Touch of Jazz production company in his native Philadelphia. Among the artists that Jazzy Jeff has helped develop are Eric Roberson, Jill Scott, Musiq Soulchild, Eminem, the Roots, Raheem DeVaughn, Darius Rucker, Talib Kweli, Floetry, Rhymefest, and many more. Despite separating from Will Smith as a music partner, they remain close friends and occasionally work together.
Some songs by Smith were produced by Townes, and he has performed on some songs by Smith such as "So Fresh" and "Potnas". In addition, he appeared in several of Smith's music videos such as "Will2K" and "Freakin' It". On some occasions, he made appearances with Smith at live concerts, producing DJ scratches. On July 2, 2005, DJ Jazzy Jeff performed with Smith at the Live 8 concert in Philadelphia. Moreover, Smith acknowledges him in his music such as "Comin' to the Stage" from the album Lost and Found and "Potnas" from his album Willennium.